Deficit de pseudocolinesteraza – reprezinta o conditie care determina o cresterea sensibilitatii la relaxante musculare determinata printr-o mutatie in gena BCHE ce scade productia de pseudoclinesteraza
- normozigoti – enz suficienta pt metabolizarea SCo in 4-6 min
- heterozigoti atipici – nivel ↓ de enzima, metab SCo in 10-20 min
- homozigoti atipici – def marcata, afinitate ↓ pt Sch, metab SCh in 2 h → suport ventilator
Dibucaina – inh pseudocolinesteraza
- N 80%
- atipica 20 %
- heterozigoti atipici 40-60%
Dibucaine number = procentul de pseudocolinesteraza inhibata, proportional cu fct colinesterazei si independent de cant de enzima
Determinarea de pseudocolinesteraza
- cantitativ – dozare – u/l
- calitativ – nr dibucaina